Along with other varanid lizards, such as the Komodo dragon and the lace monitor, megalania belongs to the proposed clade Toxicofera, which contains all known reptile clades possessing toxin-secreting oral glands, as well as their close, non-venomous relatives, including Iguania, Anguimorpha, and Serpentes.[15][16][17] Being a member of Anguimorpha, megalania may have been venomous and if so, would be the largest venomous vertebrate known.[18]
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