Nuclear receptors oor Spaans
Nuclear receptors
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Receptores nucleares
These nuclear receptors are transcription factors involved in lipogenesis, a key process in fat metabolism.
Estos receptores nucleares son factores de transcripción que participan en la lipogénesis, un proceso clave en el metabolismo de las grasas.
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Advanced filtering
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Within all cells including microglia, nuclear receptors (NRs) can sense the presence of certain hormones and other molecules.
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As with all other proteins, the DNA-binding function of nuclear receptors is based on their shape.
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These nuclear receptors have several common structural features (Figure 42–12).
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As a consequence, nuclear receptors play key roles in both embryonic development and adult homeostasis.
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There is some evidence that a multiplicity of thyroid nuclear receptors exists, including one for nerve tissue.
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DAX1 acts by binding to a related nuclear receptor SF-1 (steroidogenic factor-1).
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SRC-1 Steroid receptor coactivator 1 NCoA-1 Nuclear receptor coactivator 1 B.
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They bind to a family of largely cytoplasmic proteins known as nuclear receptors.
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[B] The two main classes of nuclear receptors.
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Most ligand–nuclear receptor complexes function as transcription factors (see Figure 11-44).
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These nuclear receptors have several common structural features (Figure 42–12).
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Direct repeats FIGURE 42–12╇ The nuclear receptor superfamily.
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[D] Type 4: nuclear receptors that control gene transcription.
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Both are members of the nuclear receptor super-family (see Chapter 2).
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[A] Structure of a nuclear receptor, showing the different domains.
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A number of different members of the nuclear-receptor superfamily regulate lipid metabolism.
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SRC-1,2,3 Steroid receptor coactivator 1, 2, and 3 NCoA-1 Nuclear receptor coactivator 1 B.
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Cell proliferation, differentiation and death are controlled by different transcription factors including the non-steroid nuclear receptors (nsNR).
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NCOA1 is recruited to DNA promotion sites by ligand-activated nuclear receptors.
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Nuclear receptors and lipid metabolism: cardiovascular implications
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Many ligands that associate with membrane or nuclear receptors eventually converge on CBP/p300.
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Many ligands that associate with membrane or nuclear receptors eventually converge on CBP/p300.
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The AFs can interact with each other, with the liganded nuclear receptors, or with coregulators.
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Testosterone and dihydrotestosterone modify gene transcription by interacting with nuclear receptors.
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These nuclear receptors are transcription factors involved in lipogenesis, a key process in fat metabolism.
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