antibody combining site oor Spaans
antibody combining site
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paratopo
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voorbeelde
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Voorbeelde moet herlaai word.
This process, known as class switching, occurs without changing the combining site of the antibodies synthesized.
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The antibody molecule has at least two combining sites, or Fab fragments (see Fig. 35-6).
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An antibody binding site composed of synthetic polypeptide loops that interact cooperatively with the antigen is combined and used to produce templates.
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It depends on the closeness of stereochemical fit between antibody combining sites and antigen determinants, on the size of the area of contact between them, and on the distribution of charged and hydrophobic groups.
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Other such antibodies may combine a TAT binding site with a binding site for another protein.
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Other such antibodies may combine an Cln101 binding site with a binding site for another protein.
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Biological, chemical and/or biochemical preparations, namely, reagents and kits consisting of one or more of the following (including various combination thereof)-proteins, antibodies, nucleic acid arrays, protein arrays, nucleic acid molecules, peptides, kinases, growth factors, PCR fragments, cDNA libraries, RNA, RNAi, vectors, enzymes, DNA polymerases, reverse transcriptases, molecules, clones, genes, cell, recombination proteins and sites, restriction enzymes, primers, plasmids, nucleotides, and reagents all for medical diagnostic laboratory use
Debe ser verdad- GraciastmClass tmClass
Biological, chemical and/or biochemical preparations, namely, reagents and kits consisting of one or more of the following (including various combination thereof)-proteins, antibodies, nucleic acid arrays, protein arrays, nucleic acid molecules, protein ladders, nucleic acid ladders, peptides, kinases, growth factors, PCR fragments, cDNA libraries, vectors, enzymes, DNA polymerases, reverse transcriptases, molecules, clones, genes, cell, recombination proteins and sites, restriction enzymes, primers, nucleotides, plasmids, and reagents all for scientific medical research, or research use
Presupuesto total: # eurostmClass tmClass
Structurally, the immunoadhesins comprise a fusion of the adhesin amino acid sequence with the desired binding specificity which is other than the antigen recognition and binding site (antigen combining site) of an antibody (i.e. is "heterologous") and an immunoglobulin constant domain sequence. The immunoglobulin constant domain sequence in the immunoadhesin may be obtained from any immunoglobulin, such as IgGj, IgG2, IgG3, or IgG4 subtypes, IgA, IgE, IgD or IgM. Immunoadhesins are described in, for example, U.S. Patent No. 5,116,964.
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The large population of antibody diversity is generated by random combinations of a set of different gene segments encoding the antigen-binding sites (or paratopes), which subsequently undergo random mutations in this region of the antibody gene, which results in a even greater diversity.
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Structurally, the immunoadhesins comprise a fusion of the adhesin amino acid sequence with the desired binding specificity which is other than the antigen recognition and binding site (antigen combining site) 10 of an antibody (i.e. is "heterologous") and an immunoglobulin constant domain sequence. The immunoglobulin constant domain sequence in the immunoadhesin is preferably derived from yl, y2, or y4 heavy chains since immunoadhesins comprising these regions can be purified by protein A affinity chromatography (Lindmark et al., J. Immunol. Meth.
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