beta-catenin oor Spaans

beta-catenin

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Catenina beta

en
human protein
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Voorbeelde moet herlaai word.
In a second step, the beta catenin and ras signalling pathways were integrated in the model.
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This causes the PLAG gene to be juxtaposed to the gene for beta catenin.
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In neural progenitor cell proliferation in adult mouse subventricular The role of beta-catenin signaling.
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In addition, the protein becomes more amenable to phosphorylation, a modification that further inhibits beta-catenin intermolecular interaction.
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Comparison of the beta-catenin molecular sequence across different species indicated that this mechanosensitive site is conserved.
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These observations clearly indicate that during development beta-catenin serves as the primary sensor of mechanical forces.
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The findings suggest that the joint's formation failed because of the local loss of beta-catenin activity.
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The researchers' results show that beta-catenin plays a key role in determining whether blood cells form or not.
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Scientific studies indicate that beta-catenin-independent Wnt signalling plays a more important role in the function of endocrine islet cells.
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Project scientists planned to test candidate molecules responsible for this interaction in transgenic mice of inducible beta-catenin and ras signalling.
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The scientists showed that the Wnt/beta-catenin signalling pathway is activated in basal cell carcinoma-initiating cells just after oncogene expression.
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Furthermore, beta-catenin seems to make cells take decisions about their fate before they leave the stem cell compartment in the bone marrow.
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Signalling through beta-catenin led to attenuation of expression of genes that are positively regulated by the ras signalling module and vice versa.
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For this purpose, they chose to study the beta-catenin pathway, which is involved in the mechanical induction of mesoderm differentiation at gastrulation.
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The findings of the study could also aid cancer research as mechanical activation of beta-catenin by tumour cells in healthy tissues is carcinogenic.
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A significant finding was that DKK3 activates Wnt pathways upstream of the switch between Wnt signalling pathways, whether beta-catenin-independent or beta-catenin-dependent.
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By coupling the modelling approach with whole genome expression profiling from hepatocytes with activated beta-catenin or ras signalling, scientists identified negative interactions between both pathways.
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'We modified one element of the pathway, a protein called beta-catenin, so that it was stuck in 'transmission mode',' explained Peggy Kirstetter of the EMBL.
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Previous results demonstrated that activation of the Wnt/beta-catenin pathway in embryonic stem cells remarkably enhances cell fusion-mediated reprogramming with somatic cells in vitro.
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In mice, activation of the beta-catenin pathway in response to mechanical strain is observed in bone mass formation and homeostasis, as well as in adipogenesis.
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With respect to cancer, the work will investigate the interaction of 14-3-3 proteins with the oestrogen receptor alpha and the beta-catenin interacting protein CHIBBY.
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With this in mind, scientists on the EU-funded BCATENIN_MECHANICS (Mechanical activation of beta-catenin signalling) study set out to provide in vivo insight into this largely unexplored mechanism.
Durante un periodo transitorio de # días como máximo a partir de la fecha de aplicación de la presente Decisión, los Estados miembros autorizarán la importación de esperma de animales domésticos de la especie bovina y carne fresca de animales domésticos de la especie porcina con arreglo a los modelos de certificado vigentes antes de la fecha de aplicación de la presente Decisióncordis cordis
Past studies have indicated that the Wnt/beta-catenin signalling pathway contributes significantly in sustaining this joint-cell 'fate' and ensuring that the joint cells do not differentiate into cartilage.
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One of the key features of both intestinal and mammary cancer was an activated Wnt signalling pathway, clearly demonstrating that its effector molecule, beta catenin, represents a functional marker of CSCs.
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Using Drosophila as a model organism and state-of-the-art live imaging techniques, scientists discovered that the strain generated during drosophila gastrulation weakens the interaction of beta-catenin with other proteins.
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71 sinne gevind in 9 ms. Hulle kom uit baie bronne en word nie nagegaan nie.