cementoblast oor Spaans
cementoblast
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A cell that forms from the follicular cells around the root of a tooth, and whose biological function is cementogenesis.
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The cementoblasts differentiate from follicular cells, which can only reach the surface of the tooth's root once Hertwig's Epithelial Root Sheath (HERS) has begun to deteriorate.
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Cementum is formed by cementoblasts, another mesenchymal derivative found in the root of the tooth.
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The cementoblasts secrete fine collagen fibrils along the root surface at right angles before migrating away from the tooth.
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The origin of the formative cementoblasts is believed to be different for cellular cementum and acellular cementum.
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The dental follicle gives rise to three important entities: cementoblasts, osteoblasts, and fibroblasts.
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Cementoblasts form the cementum of a tooth.
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In addition, amelogenins appear to aid in the development of cementum by directing cementoblasts to the tooth's root surface.
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Cementoblasts and osteoblasts are cells which also possess the ability to produce collagen.
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Therapeutic strategies directed to solving this problem aim at achieving full regeneration of periodontal tissues.1 In spite of advances experienced with respect to osteogenesis, the processes which regulate cementogenesis are not well known. For this reason our understanding of cement and periodontium regeneration is still obscure.2 Substantial advantages in the field of bone, enamel and dentin formation have taken place due to the availability of specific markers which facilitate identification of these tissues.3 In contrast to this, the lack of specific markers for cement has limited our knowledge on mechanisms that control differentiation of cementoblastic cells, cement formation as well as periodontium development.
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Several laboratories, ours included among them, after dedicated effort, have achieved isolation of several cement specific putative proteins, such as 55kDa called cement adhesion protein (CAP),4,5 a protein related and derived from human cementoblast (CP)6 a mitogenic factor known as Root Cement Growth Factor (CGF) as well as an isoform of growth factor similar to insulin (IGF-I),7 and a 72kDa protein, CEM-1.8 Complete characterization of these proteins has been an arduous and even sometimes unsuccessful task.
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The cementoblasts differentiate from follicular cells, which can only reach the surface of the tooth's root once Hertwig's Epithelial Root Sheath (HERS) has begun to deteriorate.
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Cementum formation is called cementogenesis and occurs late in the development of teeth. Cementoblasts are the cells responsible for cementogenesis. Two types of cementum form: cellular and acellular.[35]
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Get a biological close: the cementoblasts of the periodontal stump will produce cement that closes the apex, achieving the success of endodontic treatment.
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As the cementoblasts move, more collagen is deposited to lengthen and thicken the bundles of fibers.
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Noncollagenous proteins, such as bone sialoprotein and osteocalcin, are also secreted.[36] Acellular cementum contains a secreted matrix of proteins and fibers. As mineralization takes place, the cementoblasts move away from the cementum, and the fibers left along the surface eventually join the forming periodontal ligaments.
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