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The consortium followed a phage display-based approach to screen large combinatorial libraries of antibody mimetics.
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Acylhydrazone-based dynamic combinatorial libraries: study of the thermodynamic/kinetic evolution, configurational and coordination dynamics
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The kinetic and thermodynamic selectivity of acylhydrazone formation in dynamic combinatorial libraries (DCL) is described.
Diles que me dejen un pedazoscielo-abstract scielo-abstract
Ligation reactions are used to synthesise combinatorial libraries, label biomolecules and perform supramolecular synthesis.
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Researchers exploited dynamic combinatorial chemistry and the creation of dynamic combinatorial libraries, powerful tools for discovery.
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Dynamic molecular networks are usually used to create dynamic combinatorial libraries (DCLs).
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New instruments were developed and sold for forensic human identification, protein identification and characterization, metabolite pathway identification, and lead compound identification from combinatorial libraries.
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Monobodies with high affinity and specificity for different target molecules can be generated from combinatorial libraries in which portions of the FN3 scaffold are diversified.
El dueño te llamó un taxi, trató de conseguir a tu hijo para venir a recogerte, pero no pudo encontrarloWikiMatrix WikiMatrix
At Intelligent Pharma the performance of CHIRON was tested using three different experimentally analyzed combinatorial libraries bearing around 15000 molecules each. Experimentally determined biological activities were used as the driving force of the molecule search.
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The molecule search is driven by a genetic algorithm, which selects more active molecules from generation to generation. For the first generation, CHIRON chooses some molecules from the specified combinatorial library on bases of structural diversity.
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Accelerated Hit Detection in Combinatorial Chemistry Libraries.
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To this end, they designed and synthesised building blocks capable of disulphide exchange and characterised them both within and on the membrane of the vesicles.In parallel, diffusion across the vesicle membrane was examined by using different combinatorial libraries.
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CHIRON can be used for combinatorial chemistry projects to efficiently perform hit/lead optimization. This implies that CHIRON finds the most active molecule of a combinatorial library without the necessity to actually synthesize and analyze the large majority of all molecules (more than 80%).
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When comparing the properties of compounds in combinatorial chemistry libraries to those of approved drugs and natural products, Feher and Schmidt noted that combinatorial chemistry libraries suffer particularly from the lack of chirality, as well as structure rigidity, both of which are widely regarded as drug-like properties.
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The new materials have been tested in combinatorial solar cell libraries to investigate their properties under real-world operating conditions.
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Software library for combinatorial and geometric algorithms
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The Parsec library , a monadic combinatorial parser written entirely in Haskell, simplifies parsing.
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As chirality and rigidity are the two most important features distinguishing approved drugs and natural products from compounds in combinatorial chemistry libraries, these are the two issues emphasized in so-called diversity oriented libraries, i.e. compound collections that aim at coverage of the chemical space, instead of just huge numbers of compounds.
Pues no funcionoWikiMatrix WikiMatrix
High-throughput screening technologies allow large numbers of compounds (libraries- see combinatorial biochemistry) to be screened for specific activities, such as looking for a compound to bind to a particular receptor, or inactivate a specific enzyme
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High-throughput screening technologies allow large numbers of compounds (libraries – see combinatorial biochemistry) to be screened for specific activities, such as looking for a compound to bind to a particular receptor, or inactivate a specific enzyme.
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One example of combinatorial synthesis is its use in creating a library of benzodiazepines (Section 31.5).
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Whereas though in many other areas of applied computing like statistics and linear programming, software libraries exist, until now there was no corresponding library for geometrical and combinatorial computing.
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Structural biology and combinatorial chemistry have been superseded by high-throughput screening of chemical libraries.
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Keywords: Bacteriophages, combinatorial libraries, phage display technology, biopaning, infectious diseases, peptides, antibodies.
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Once created, protein aptamers are usually isolated from combinatorial libraries through a selection technique.
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