maraviroc oor Spaans
maraviroc
en
Category:Drugs A specific drug used in the treatment of HIV to inhibit viral entry into cells.
Vertalings in die woordeboek Engels - Spaans
Maraviroc
en
chemical compound
es
compuesto químico
It is not known whether maraviroc is secreted into human milk
Se desconoce si maraviroc se excreta en la leche humana
Geskatte vertalings
Vertoon algoritmies gegenereerde vertalings
Prenteboek
voorbeelde
Advanced filtering
Voorbeelde moet herlaai word.
The maraviroc-resistant viruses remained CCR#-tropic and there was no conversion from a CCR#-tropic virus to a CXCR#-using virus
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However, co-administration of CELSENTRI with tenofovir (substrate for renal elimination) and Cotrimoxazole (contains trimethoprim, a renal cation transport inhibitor), showed no effect on the pharmacokinetics of maraviroc
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After intravenous administration (# mg), the half-life of maraviroc was # h, # % of the dose was excreted unchanged in the urine and the values of total clearance and renal clearance were # L/h and # L/h respectively
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Maraviroc/Efavirenz (# mg twice daily/# mg once daily) Integrase strand transfer inhibitor
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In the presence of metabolic inhibitors, renal clearance may account for up to # % of total clearance of maraviroc and hence renal impairment may result in increased maraviroc exposures in this case (see sections # and
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However, renal clearance contributes less than # % of maraviroc total clearance in the absence of CYP#A# inhibitors, therefore the impact of renal impairment on maraviroc elimination should be minimal
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Maraviroc is a substrate of cytochrome P# CYP#A
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Other developmental parameters of these offspring, including fertility and reproductive performance, were not affected by the maternal administration of maraviroc
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At higher exposure of maraviroc a potential inhibition of CYP#D# cannot be excluded
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Each film-coated tablet contains either # mg or # mg of maraviroc
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In vitro studies also indicate that polymorphic enzymes CYP#C#, CYP#D# and CYP#C# do not contribute significantly to the metabolism of maraviroc
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Maraviroc and VIRAMUNE can be co-administered without dose adjustments
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Maraviroc # mg QD
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Vicriviroc, similar to maraviroc, is currently undergoing clinical trials for FDA approval.
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Maraviroc selectively binds to the human chemokine receptor CCR#, preventing CCR#-tropic HIV-# from entering cells
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Elimination: a mass balance/excretion study was conducted using a single # mg dose of #C-labeled maraviroc
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In the absence of metabolic inhibitors, renal clearance accounts for less than # % of total clearance of maraviroc and hence renal impairment is not expected to significantly alter maraviroc exposures
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Cmax: # (#, #) Maraviroc concentrations not measured, no interaction expected
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In vitro and in vivo studies showed that maraviroc has a potential to increase QTc interval at supratherapeutic doses with no evidence of arrhythmia
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Maraviroc is the major circulating component (approximately # % radioactivity) following a single oral dose of # mg
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Aplaviroc, an agent similar to maraviroc and vicriroc.
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Maraviroc did not impair mating or fertility of male or female rats, and did not affect sperm of treated male rats up to # mg/kg
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206 sinne gevind in 8 ms. Hulle kom uit baie bronne en word nie nagegaan nie.