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Nuclear Genes Can Modify the Phenotype of mtDNA Diseases.
Nadie sabe a qué se deben, pero enloquecen a los búfalosLiterature Literature
Transport proteins involved in the formation of the intra-nuclear aggregates could be modulated to alleviate the phenotype of ataxin 3 mutations.
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The nuclear gene F in the presence of “poky” cytoplasm produces a fast-poky phenotype (Problem 14.3).
Es... es un poco difícil de explicar a un profanoLiterature Literature
A combination of proton nuclear magnetic resonance (NMR) spectroscopy and ultra-performance-liquid-chromatography (UPLC) linked to mass spectrometry (MS) was used for metabolic phenotyping.
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I applied an integrative approach combining genotypic (mitochondrial and nuclear markers) and phenotypic (plumage coloration and vocalizations) evidence.
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Evaluation of nuclear morphology with Hoechst or DAPI showed a phenotype policarion.
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The hypothesis is that if cancer is nuclear-gene driven and the phenotype of cancer is dysregulated cell growth, meaning if genetic mutations are responsible for the observable characteristics of the disease, then those abnormal genes should be expressed in the new cytoplasm.
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The hypothesis is if cancer is nuclear-gene driven and the phenotype of cancer is dysregulated cell growth, meaning if genetic mutations are responsible for the observable characteristics of the disease, then those abnormal genes should be expressed in the new cytoplasm.
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The hypothesis is that if cancer is nuclear-gene driven and the phenotype of cancer is dysregulated cell growth, meaning if genetic mutations are responsible for the observable characteristics of the disease, then those abnormal genes should be expressed in the new cytoplasm.
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The team developed and phenotyped two mapping populations from the nuclear male-sterile line CL-1 and the high oleic acid lines CR-6 (>75% oleic acid) and CR-9 (>84%).
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These proteins are commonly referred as Sm nuclear antigens due to their antigenic nature.Genomic Imprinting: The variable phenotypic expression of a GENE depending on whether it is of paternal or maternal origin, which is a function of the DNA METHYLATION pattern.
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To do so, here I used genetic data from nuclear microsatellites (12 nuSSRs) and single nucleotide polymorphisms (384 and 6,100 SNPs), and phenotypic data, measured in common gardens replicated in multiple environments.
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Current studies analyze the phenotypic changes of the cells, molecular markers, modifications of the nuclear and cytoskeletal architecture, and in vivo studies in animal models, where immunophilins are being tested as potential pharmacologic targets for neuronal regeneration and neuroprotection.
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“Even though gametes are required from a man and two different women (the patient and the donor), the nuclear or genomic DNA responsible for the vast majority of phenotypical characteristics of the future baby will come from the biological mother and father, just like in a normal fertilisation process.
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Interestingly, inherited mitochondrial diseases that can be caused by mutations in genes encoded on the nuclear DNA, which encodes the vast majority of mitochondrial genes, or in genes that are encoded in mtDNA are often associated with neurodegenerative phenotypes, indicating a particular vulnerability of brain neurons to mitochondrial defects.
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The small temporal RNAs (stRNAs), let-7 and lin-4, from C. elegans, are the first 2 miRNAs discovered, and are from a class of miRNAs involved in developmental timing.Gene Expression Regulation, Developmental: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.Gene Expression: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.RNA, Messenger: RNA sequences that serve as templates for protein synthesis.
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