phosphocreatine oor Spaans
phosphocreatine
en
(biochemistry) A phosphorylated derivative of creatine that is used in muscles to store chemical energy
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fosfocreatina
Phosphocreatine is an important source of energy in the muscles, as well as a local regulator of energy metabolism.
La fosfocreatina constituye una fuente importante de energía para los músculos, así como un regulador local del metabolismo energético.
Fosfocreatina
en
chemical compound
es
compuesto químico
Oral intake of creatine increases the concentration of creatine, both free creatine and phosphocreatine, in the muscles.
La ingesta oral de creatina aumenta la concentración de creatina, tanto creatina libre como fosfocreatina, en los músculos.
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"For this reason, we can call the ATP-phosphocreatine system an ATP ""buffer"" system."
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The combined amounts of cell ATP and cell phosphocreatine are called the phosphagen energy system.
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Creatine is found in very high concentrations in the muscles, principally in phosphorylated form, i.e. as phosphocreatine.
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This resource is short lasting because oxygen is required for the resynthesis of phosphocreatine via mitochondrial creatine kinase.
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This effect keeps the concentration of ATP at an almost constant high level as long as any phosphocreatine remains.
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Muscle cells also use phosphocreatine as a source of phosphate to produce ATP.
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Phosphocreatine reversibly combines with ADP to form ATP and creatine in the cell.
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When ATP utilization increases, the energy in phosphocreatine is transferred rapidly back to ATP.
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Oral intake of creatine increases the concentration of creatine, both free creatine and phosphocreatine, in the muscles.
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The overall reaction, which goes in both directions is phosphocreatine + ADP ↔ creatine + ATP.
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This effect keeps the concentration of ATP at an almost constant level for as long as any phosphocreatine remains.
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For this reason, we can call the ATP-phosphocreatine system an ATP “buffer” system.
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Phosphocreatine is produced from ATP and creatine in mammalian muscle cells at rest.
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Creatine is found in very high concentrations in the muscles, particularly in the form of phosphocreatine which plays an important role in muscle energy metabolism.
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Furthermore, most muscle cells have two to four times as much phosphocreatine as ATP.
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What ATP/ADP ratio is necessary to maintain a phosphocreatine/creatine ratio of 20:1?
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Intake of creatine can enhance the rate of ATP conversion and phosphocreatine resynthesis in the muscles, as well as accelerate muscle relaxation after contraction through an increase in creatine concentration in the muscle fibres.
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Phosphocreatine is the chemical fuel source.
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Changes in resting myocellular glycogen and phosphocreatine (PCr) were determined with Magnetic Resonance Spectroscopy (13C- and31P-MRS, respectively).
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The combination of the cellular ATP and phosphocreatine system is called the phosphagen energy system.
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Phosphocreatine is an important source of energy in the muscles, as well as a local regulator of energy metabolism.
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In the muscles of vertebrates, large amounts of phosphocreatine are formed during times of ample ATP supply.
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ATP and/or phosphocreatine produced in mitochondria are transferred to the cytosol across the mitochondrial outer membrane, mainly through the porins (voltage-dependent anion channel, VDAC).
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In other words, phosphocreatine acts as high-energy reserve in a coupled reaction; the energy given off from donating the phosphate group is used to regenerate the other compound - in this case, ATP.
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In resting muscle, the concentration of phosphocreatine is about fivefold higher than that of ATP.
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