pigmentary retinopathy oor Spaans
pigmentary retinopathy
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retinitis pigmentosa
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Two thirds of patients have a pigmentary retinopathy (Hayflick et al, 2003).
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Pigmentary retinopathy
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Pigmentary retinopathy
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Pigmentary retinopathy occurs in 33% and neuropathy in 25%.
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— Pigmentary retinopathy
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— Pigmentary retinopathy
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Described by Thomas Kearns and George Sayre who reported a case with presence of the triad of external ophthalmoplegia, pigmentary retinopathy and cardiac conduction blocks, the latter being decisive alteration in the forecast, as well as the number of affected organs.
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Eye findings include cataracts, glaucoma, pigmentary retinopathy, nystagmus, corneal clouding and optic nerve atrophy.
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The diagnostic criteria most widely accepted in the literature are a triad: progressive external ophthalmoplegia, pigmentary retinopathy and disorders of cardiac conduction.
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Pigmentary retinopathy has been observed after long-term treatment, mostly in patients receiving doses exceeding the recommended maximum of 800 mg/day.
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Due to the large spectrum of clinical manifestations, the KSS has several differential diagnoses, among these other syndromes mitochondria encephalomyopathies, CCB and oftalmopatias4,9.The most widely accepted diagnostic criteria in the literature are the triad: progressive external ophthalmoplegia, pigmentary retinopathy and CCB.
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This rare illness was described by Thomas P. Kearns y George P. Sayre in 1958 through the report of a case which presented the clinical triad, external ophthalmoplegia, pigmentary retinopathy and cardiac conduction defects; being this last alteration the one that determines the prognosis.
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The onset of clinical manifestations of this patient, even in childhood, coincides with the literature, since the KSS is characterized by ophthalmoplegia and pigmentary retinopathy, usually manifests before the age of twenty; however other changes are associated in several published case reports such as protein concentration, proximal myopathy, thyroid disorders, hypoparathyroidism, Addison’s disease, dysphasia in achalasia and renal tubular acidosis, short stature, cerebellar ataxia and cardiac conduction disturbance were also identified in the case reported3,6,8.
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To do this we consulted different published papers of Cuban and foreign doctors that help us to arrive to the conclusion that optic neuropathy should be consider as a of mitochondrial disease, that we have to think about it when having a patient with pigmentary retinopathy associated to a indefinite sistemic or neurological disease and that because of a punctual mutation in the mitochondrial DNA will be inherited maternally and defects in the nuclear DNA, even affecting it to the mitochondrion, will be transmitted by classic Méx.
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Ocular findings reported in infants with presumed or confirmed congenital Zika virus infection have included chorioretinal atrophy or scarring, pigmentary changes, optic nerve hypoplasia, optic disc pallor, increased optic disc cupping, hemorrhagic retinopathy and abnormal retinal vasculature (10–12).
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19 sinne gevind in 9 ms. Hulle kom uit baie bronne en word nie nagegaan nie.