Compounds of formula (I), or retroenantiomers thereof unacylated at their N-terminal end and having the configuration of the aminoacid with the R2 side chain non-inverted when R2 is -CH(CH3)(OH), wherein R0 is CH3-(CH2)m-, CH3-O-(CH2CH2O)2CH2- or phenyl-(CH2)x-; m is an integer between 7 and 10; x is an integer between 1 and 3; R1, R3, R4, R7 and R8 are independently selected from the formula GF-(CH2)n-, wherein n is an integer between 1 and 4; and GF is -NH2, -NH-C(=NH)-NH2 or 4-imidazolyl; R2 is -CH(CH3)(OH), -CH(CH3)2, -CH2NH2 or -CH2OH; R5 and R6 are -(C1-C4-linear or branched alkyl, -(CH2)-R10, -CH2-CH2-S-CH3 or -CH2-CH2-S(=O)-CH3; R9 is H or Gly-spermide; and R10 is phenyl, 3-indolyl, 4-imidazolyl, 4-hydroxyphenyl, α- or β-naphthyl or 2-, 3- or 4-pyridyl, have been found to be useful in the treatment of bacterial infections.
Los compuestos de formula (I), o retroenantiόmeros de los mismos no acilados en su extremo N-terminal y con la configuraciόn del aminoácido con la cadena lateral R2 no invertida cuando R2 es -CH(CH3)(OH), donde: R0 es CH3-(CH2)m-, CH3-O-(CH2CH2O)2CH2- o fenil-(CH2)x-; m es un entero entre 7 y 10; x es un entero entre 1 y 3; R1, R3, R4, R7 y R8 se seleccionan independientemente de la formula GF-(CH2)n- donde n es un entero entre 1 y 4; y GF es -NH2, -NH-C(=NH)-NH2 o 4-imidazolilo; R2 es -CH(CH3)(OH), -CH(CH3)2, -CH2NH2 o -CH2OH; R5 y R6 son -(C1-C4-alquilo lineal o ramificado, -(CH2)-R10, -CH2-CH2-S-CH3 o -CH2-CH2-S(=O)-CH3; Rg es H o Gly-espermida; y R10 es fenilo, 3-indolilo, 4-imidazolilo, 4-hidroxifenilo, α o β- naftilo o 2-, 3- o 4-piridilo, se ha encontrado que son ύtiles en el tratamiento de infecciones bacterianas.patents-wipo patents-wipo