DNA topoisomerase
ADN-topoisomerasa
topoisomerase oor Spaans
topoisomerase
en
(biochemistry) Any of several enzymes that effect the topology of DNA, especially ones that relax supercoiling
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Topoisomerasa
It blocks an enzyme called topoisomerase I, which is involved in the division of DNA
Inhibe la actividad de una enzima, llamada topoisomerasa I, que interviene en la división del ADN
topoisomerasa
It blocks an enzyme called topoisomerase I, which is involved in the division of DNA
Inhibe la actividad de una enzima, llamada topoisomerasa I, que interviene en la división del ADN
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The 'Topoisomerase function in genome and epigenome regulation during neuronal differentiation' (Toponeuronal) project set out to reveal the contribution of Top2ß activity to epigenetic regulation of neuronal differentiation.
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Such breaks are not considered DNA damage because they are a natural intermediate in the topoisomerase biochemical mechanism and are immediately repaired by the enzymes that created them.
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First- and second-generation fluoroquinolones selectively inhibit the topoisomerase II ligase domain, leaving the two nuclease domains intact.
Globalmente, el rendimiento de las inversiones se mantuvo negativo y se deterioró en #,# puntos porcentuales durante el período consideradoWikiMatrix WikiMatrix
This reaction releases free topoisomerase I (E) and intact double stranded DNA (step iv).
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Type II topoisomerases make a transient break in both strands of a DNA duplex.
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(b) X-ray diffraction pattern for a topoisomerase crystal collected on a solid-state detector.
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One of these, directed against DNA topoisomerase I (anti-Scl 70), is highly specific.
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Topoisomerase I is the antigen recognized by Anti Scl-70 antibodies in scleroderma.
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Molecules of this type collect in bacteria lacking a specific topoisomerase.
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Biochemical studies of Leishmania have detected differences between the two drugs with regard to DNA topoisomerase I inhibition, a phenomenon that possibly impacts treatment efficacy.
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In on-cology, the studies of topoisomerases II are important because these enzymes are target to many important agents used in chemotherapy.
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Topoisomerase IV also undergoes mutations.
AbsolutamenteLiterature Literature
However, as moxifloxacin inhibits both topoisomerase # and # with similar activity in some Gram-positive bacteria, such bacteria may be resistant to other quinolones, but susceptible to moxifloxacin
Pero le falta la aportación de cómo entienden las organizaciones de la sociedad civil latinoamericana y caribeña que se tiene que actuar, en algunos vectores estratégicos-el papel del Estado y sus instituciones, la fiscalidad, la educación, la sanidad, la seguridad social, las infraestructuras económicas y la política industrial, los marcos de relaciones laborales, la participación de la sociedad civil, la protección de los derechos humanos-, para alcanzar una mayor nivel de cohesión social en la regiónEMEA0.3 EMEA0.3
The topoisomerases II are also phosphoproteins, being targets of kinases like PKC, caseine kinase II, CDC2 and,in vitro, the phosphorylation can activate their catalytic activity.
Según la directriz del CHMP sobre Sistemas de Gestión de Riesgos para medicamentos de uso humano, cualquier PGR actualizado debe presentarse al mismo tiempo que el siguiente Informe Periódico de Seguridad (PSUR) actualizadospringer springer
Camptothecin, derived from a Chinese ornamental tree, inhibits topoisomerase I, an enzyme that allows DNA unwinding.
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Topoisomerase IV - plays a critical role in completion of a round of replication.
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In vitro resistance to moxifloxacin is acquired through a stepwise process by target site mutations in both type # topoisomerases, DNA gyrase and topoisomerase
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Topoisomerases II are enzymes that play an important role in processes like transcription, duplication and chromosome segregation.
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His Ph.D., granted in 1980 while under the guidance of Nicholas R. Cozzarelli, involved the study of DNA topoisomerases.
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Some anticancer agents, for example doxorubicin, act on the mammalian topoisomerase II.
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The aims of this study were to describe and quantify structural chromosomal aberrations induced by 5 flavones,2 isoflavones and a topoisomerase II chemotherapeutic inhibitor in Fanconi anemia lymphocytes in order to determine chromosomal numbers changes and/ or type of chromosomal damage.
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Genes associated with this resistance profile were found in A. baumannii ABIBUN 107m genome serino β-lactamases (blaADC-38, blaOXA-64, blaOXA-23, bla ampC-like, bla amp(H)-like), metallo β-lactamase_B; High Molecular Mass penicillin binding proteins, ISAba1 type insertion sequences, mutations of DNA gyrase and topoisomerase IV subunit A (gyrA and parC); aminoglycoside modifying enzymes (aphA-like, aadA-like); choramphenicol acyltransferase (cat) and dehydropteroate synthase (sul-1).
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contain a variety of topoisomerases, which can be divided into two classes.
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Researchers were able to mimic and rescue the capacity of Aire by the anti-cancer drug etoposide, which inhibits topoisomerase-2 function.
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The anti-tumour activity of topotecan involves the inhibition of topoisomerase-I, an enzyme intimately involved in DNA replication as it relieves the torsional strain introduced ahead of the moving replication fork
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