whereas DEHP has been shown to adversely affect the endocrine system of mammals primarily through in vivo findings on reduced foetal testosterone; whereas these findings are further substantiated by mechanistic findings, also in vivo, of down-regulation of genes in the steroidogenic biosynthesis pathway; whereas the spectrum of adverse effects observed in rats include increased nipple retention, decreased anogenital distance, genital malformations, a reduced number of spermatocytes and testicular changes including multinucleated gonocytes, tubular atrophy and Leydig cell hyperplasia;
Asetuksen (EY, Euratom) N:o #/# #a artiklaa sovelletaan soveltuvin osin valittaessa ulkopuolisia asiantuntijoitaeurlex-diff-2017 eurlex-diff-2017