caspase oor Fins
caspase
en
(biochemistry) Any of several intracellular proteolytic enzymes that mediate apoptosis
Vertalings in die woordeboek Engels - Fins
kaspaasi
Geskatte vertalings
Vertoon algoritmies gegenereerde vertalings
voorbeelde
Advanced filtering
Voorbeelde moet herlaai word.
Scientific research test kit consisting of buffers, caspase substrate and inhibitor, and luciferase substrate for detection of protesease activity of caspase-3
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PMID: 19863553Legionella pneumophila has become a model system to decipher the non-apoptotic functions of caspases and their role in immunity.
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Western blotting indicated changes in expression of Bax and Bcl-2 proteins resulting in an increase in Bax:Bcl-2 ratio and upregulation of cytosolic levels of cytochrome c and Smac/Diablo, suggesting involvement of mitochondria-dependent caspase cascade in apoptosis.
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Interestingly, caspase-3 is activated in permissive cells during early stages of infection. However, caspase-3 activation does not lead to apoptosis until late stages of infection because it is associated with potent Dot/Icm-mediated anti-apoptotic stimuli that render the infected cells resistant to external apoptotic inducers.
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Caspases (4 members)
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Therefore, the role of caspase-1 and non-apoptotic functions of executioner caspases are temporally and spatially modulated during infection by L. pneumophila, which determine permissiveness to intracellular bacterial proliferation.
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As caspase-3 is the executioner of the cell, we tested the hypothesis that L. pneumophila triggers anti-apoptotic signalling within the infected human macrophages to halt caspase-3 from dismantling the cells.
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Increased caspase-3 activity also cleaved inhibitor of caspase-3-activated DNase and poly(ADP-ribose) polymerase.
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