linkage disequilibrium
Desequilibrio de ligamento
disequilibrium oor Galisies
disequilibrium
en
the loss of equilibrium or stability, especially due to an imbalance of forces
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GOLD - Graphical Overview of Linkage Disequilibrium TASSEL -software to evaluate linkage disequilibrium, traits associations, and evolutionary patterns rAggr - finds proxy markers (SNPs and indels) that are in linkage disequilibrium with a set of queried markers, using the 1000 Genomes Project and HapMap genotype databases.
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In spite of its name, linkage disequilibrium may exist between alleles at different loci without any genetic linkage between them and independently of whether or not allele frequencies are in equilibrium (not changing with time).
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This makes it difficult to compare the level of linkage disequilibrium between different pairs of alleles.
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White maize lines had increased diversity and no evidence of linkage disequilibrium associated with a selective sweep.
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Both the frequency of structural mutations and the promoter polymorphisms that are in strong linkage disequilibrium vary among ethnic groups resulting in seven major haplotypes: HYPA, LYQA, LYPA, LXPA, LYPB, LYQC and HYPD.
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Behavior is linked to genetics which therefore means that when a behavioral trait is selected for, a physical trait may also be selected for due to mechanisms like linkage disequilibrium.
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Furthermore, it is also possible to define linkage disequilibrium among three or more alleles, however these higher-order associations are not commonly used in practice.
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If at some time we observe linkage disequilibrium, it will disappear in the future due to recombination.
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In maize, a recent comparison of yellow and white corn genotypes surrounding Y1—the phytoene synthetase gene responsible for the yellow endosperm color, shows strong evidence for a selective sweep in yellow germplasm reducing diversity at this locus and linkage disequilibrium in surrounding regions.
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Therefore, the presence of strong linkage disequilibrium might indicate that there has been a recent selective sweep, and can be used to identify sites recently under selection.
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Linkage disequilibrium in asexual populations can be defined in a similar way in terms of population allele frequencies.
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In population genetics, linkage disequilibrium is the non-random association of alleles at different loci in a given population.
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Loci are said to be in linkage disequilibrium when the frequency of association of their different alleles is higher or lower than what would be expected if the loci were independent and associated randomly.
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In contrast, effects on a neutral locus due to linkage disequilibrium with newly appeared deleterious mutations are called background selection.
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Linkage disequilibrium is influenced by many factors, including selection, the rate of genetic recombination, mutation rate, genetic drift, the system of mating, population structure, and genetic linkage.
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This tendency is measured by finding how often two alleles occur together on a single chromosome compared to expectations, which is called their linkage disequilibrium.
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One method is to measure linkage disequilibrium, i.e., whether a given haplotype is overrepresented in the population.
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While acknowledging that many mutations are neutral, selectionists attribute changes in the frequencies of neutral alleles to linkage disequilibrium with other loci that are under selection, rather than to random genetic drift.
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Linkage disequilibrium describes a situation in which some combinations of genes or genetic markers occur more or less frequently in a population than would be expected from their distances apart.
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Furthermore, linkage disequilibrium is sometimes referred to as gametic phase disequilibrium; however, the concept also applies to asexual organisms and therefore does not depend on the presence of gametes.
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The genetics of this situation cannot be clarified in the absence of a detailed breeding program, but two loci with linkage disequilibrium is a possibility.
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As a result, the pattern of linkage disequilibrium in a genome is a powerful signal of the population genetic processes that are structuring it.
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For this reason, evolution of mutators is generally expected to happen largely in asexual species where recombination cannot disrupt linkage disequilibrium.
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Hitchhiking occurs when a neutral polymorphism is in linkage disequilibrium with a second locus that is undergoing a selective sweep.
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When one gene goes through a selective sweep, any other nearby polymorphisms that are in linkage disequilibrium will tend to change their allele frequencies too.
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