lamin oor Galisies
lamin
en
(biochemistry) Any of a class of fibrous proteins that provide structure, and regulate transcription in a cell nucleus
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Lamina
en
fibrous proteins providing structural function and transcriptional regulation in the cell nucleus
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Lamins are also found inside the nucleoplasm where they form another regular structure, known as the nucleoplasmic veil, that is visible using fluorescence microscopy.
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Since the metalloproteinase STE24 is required to process prelamin A into mature lamin A, mutations in this gene abolishing protease activity cause defects similar to laminopathies caused by prelamin A with truncated processing sites.
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In further stages, the expression pattern of lamin B1 decreases and there is a gradual increase in the expression of lamin A. Mammalian development seems to progress in a similar way.
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This allows lamin A to dissociate from the nuclear envelope membrane and fulfill nuclear functions.
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With the development of board lamination and etching techniques, this concept evolved into the standard printed circuit board fabrication process in use today.
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Lamin polypeptides have an almost complete α-helical conformation with multiple α-helical domains separated by non-α-helical linkers that are highly conserved in length and amino acid sequence.
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This proteolytic activity is performed by members of the caspase-protein family who cleave the lamins after aspartic acid (Asp) residues.
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Missense mutations in the lamin A/C rod and tail domains are the cause for a wide array of genetic disorders, suggesting that lamin A/C protein contains distinct functional domains that are essential for the maintenance and integrity of different cell lineages.
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Lamin A is further processed to remove the last 15 amino acids and its farnesylated cysteine.
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Mutations causing progeria are defective in splicing LMNA mRNA, therefore producing abnormal lamin A protein, also known as progerin.
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Most lamin B mutations appear to be lethal with mutations in lamin B1 causing death at birth in mice.
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The c-terminal tail domain contains a nuclear localization signal (NLS), an Ig-fold-like domain, and in most cases a carboxy-terminal CaaX box that is isoprenylated and carboxymethylated (lamin C does not have a CAAX box).
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Patients with classical laminopathy have mutations in the gene coding for lamin A/C (LMNA gene).
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In contrast to the phosphorylation-induced disassembly during mitosis, the nuclear lamina is degraded by proteolytic cleavage, and both the lamins and the nuclear lamin-associated membrane proteins are targeted.
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The best-known types of microbial mat may be flat laminated mats, which form on approximately horizontal surfaces, and stromatolites, stubby pillars built as the microbes slowly move upwards to avoid being smothered by sediment deposited on them by water.
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Laminated wood construction yielded more strength in rackets used through most of the 20th century until first metal and then composites of carbon graphite, ceramics, and lighter metals such as titanium were introduced.
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This version of the protein is also referred to as prelamin A. Farnesylated prelamin A is further processed into mature lamin A by a metalloproteinase removing the last 15 amino acids and its farnesylated cysteine.
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Mandela hoped to resolve the long-running dispute between Libya and the US and Britain over bringing to trial the two Libyans, Abdelbaset al-Megrahi and Lamin Khalifah Fhimah, who were indicted in November 1991 and accused of sabotaging Pan Am Flight 103.
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The mutations activate a cryptic splice site within exon 11 of the gene, thereby causing the deletion of the processing site on prelamin A. This results in an accumulation of progerin that is unable to mature into lamin A, leading to misshapen nuclei.
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B type lamins, B1 and B2, are expressed from the LMNB1 and LMNB2 genes on 5q23 and 19q13, respectively.
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Older galleries have multiple laminate layers of silk.
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With the development of the different kinds of tissue in a relatively advanced developmental stage, there is an increase in the levels of lamin A and lamin C. These findings would indicate that in its most basic form, a functional nuclear lamina requires only B-type lamins.
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The nuclear lamina appears to be an adaptation to mobility in animals as sessile organisms such as plants or fungi do not have lamins and the symptoms of many laminopathies include muscle defects.
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The exact dosage of lamin B in cells appears to be crucial for nuclear integrity as increased expression of lamin B causes a degenerative phenotype in fruit flies and leads to abnormal nuclear morphology.
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After phosphorylation by cyclin B/Cdk1, the nuclear lamina depolymerises and B-type lamins stay associated with the fragments of the nuclear envelope whereas A-type lamins remain completely soluble throughout the remainder of the mitotic phase.
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69 sinne gevind in 11 ms. Hulle kom uit baie bronne en word nie nagegaan nie.