ibogaine oor Noorse Bokmål
ibogaine
en
A naturally-occurring psychoactive compound found in a number of plants, principally iboga, and used for medicinal and ritual purposes in African spiritual traditions of the Bwiti.
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Ibogain
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chemical compound
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The last patent in the series for the use of ibogaine to treat chemical dependence was US Patent 5,152,994, Rapid Method for Interrupting or Attenuating Poly-Drug Dependency Syndromes, awarded October 6, 1992.
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Lotsof was active in promoting medical usage and further research of ibogaine and had an interest in chemical dependence patient advocacy including authoring the Ibogaine Patients' Bill of Rights.
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Research also suggests that ibogaine may be useful in treating dependence on other substances such as alcohol, methamphetamine, and nicotine and may affect compulsive behavioral patterns not involving substance abuse or chemical dependence.
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Ibogaine was first isolated from T. iboga in 1901 by Dybowski and Landrin and independently by Haller and Heckel in the same year using T. iboga samples from Gabon.
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Coronaridine Ibogaine Ibogamine Tabernanthine Voacangine The Iboga tree is the central pillar of the Bwiti spiritual practice in West-Central Africa, mainly Gabon, Cameroon and the Republic of the Congo, which uses the alkaloid-containing roots of the plant in a number of ceremonies.
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Many users of ibogaine report experiencing visual phenomena during a waking dream state, such as instructive replays of life events that led to their addiction, while others report therapeutic shamanic visions that help them conquer the fears and negative emotions that might drive their addiction.
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The first objective, placebo-controlled evidence of Ibogaine's ability to attenuate opioid withdrawal in rats was published by Dzoljic et al. in 1988.
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A synthetic derivative of ibogaine, 18-methoxycoronaridine (18-MC), is a selective α3β4 antagonist that was developed collaboratively by the neurologist Stanley D. Glick (Albany) and the chemist Martin E. Kuehne (Vermont).
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In 1957, Jurg Schneider, a pharmacologist at CIBA (now a division of Novartis), found that ibogaine potentiated morphine analgesia.
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Noribogaine is more potent than ibogaine in rat drug discrimination assays when tested for the subjective effects of ibogaine.
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A comprehensive article (Lotsof 1995) on the subject of ibogaine therapy detailing the procedure, effects and aftereffects is found in "Ibogaine in the Treatment of Chemical Dependence Disorders: Clinical Perspectives".
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No additional data was ever published by CIBA researchers on ibogaine–opioid interactions.
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Its yellow-colored roots contain a number of indole alkaloids, most notably ibogaine, which is found in the highest concentration in the root-bark.
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Complete synthesis of ibogaine was accomplished by G. Büchi in 1966.
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It is proposed that ibogaine is deposited in fat and metabolized into noribogaine as it is released.
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After ibogaine ingestion in humans, noribogaine shows higher plasma levels than ibogaine and is detected for a longer period of time than ibogaine.
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Almost 50 years later, Patrick Kroupa and Hattie Wells released the first treatment protocol for concomitant administration of ibogaine with opioids in human subjects, indicating that ibogaine reduced tolerance to opioid drugs.
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Psychoanalysts, such as Claudio Naranjo, in the sixties have described the value of ibogaine-induced oneirophrenia for inducing and manipulating free fantasy and dream-like associations in patients under treatment.
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The most-studied therapeutic effect of ibogaine is the reduction or elimination of addiction to opioids.
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Chronic pain management[edit] In 1957, Jurg Schneider, a pharmacologist at CIBA (now a division of Novartis), found that ibogaine potentiated morphine analgesia.
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Its yellow-coloured roots contain a number of indole alkaloids, most notably ibogaine, which is found in the highest concentration in the root-bark.
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