apoptosome oor Nederlands

apoptosome

naamwoord
en
(biology) A large ternary protein structure formed in the process of apoptosis

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apoptosome

en
A multisubunit protein complex involved in the signaling phase of the apoptotic process. In mammals it is typically composed of seven Apaf-1 subunits bound to cytochrome c and caspase-9. A similar complex to promote apoptosis is formed from homologou
nl
cellulaire component
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The apoptosome cleaves the pro-caspase to its active form of caspase-9, which in turn activates the effector caspase-3.
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Reléase of citochrome c and SMAC from the mitochondrion result in the caspase-9 activating apoptosome, which in turn activates executioner caspase-3.
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The first pathway activates a caspase cascade whilst the second intrinsic pathway promotes apoptosome formation.
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