ependymal cell oor Nederlands
ependymal cell
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“In mice whose ependymal cells don’t have any huntingtin, there are serious problems in the brain ”
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The ventricles of the brain contain fluid that’s circulated by beating cilia on the ependymal cells that their walls
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To study this, Saudou’s team engineered a mouse that didn’t produce any huntingtin in a single type of cells - ependymal cells.
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Ependymal cells are of particular interest here, because they use cilia on their surface to help the cerebrospinal fluid to circulate.
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At the interface between the CSF and the brain a barrier is created by a single layer of highly specialized epithelial cells also known as ependymal cells.
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Ependymal cells are not tightly connected between each other, this means that the CSF can pass into brain, allowing nutrients and other important substances to reach the neurons.
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Indeed, after stroke for example, these cells can “enter the playfield” and transform themselves from ependymal cells into neurons, trying to ameliorate the damage caused by the stroke.
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If the job of ependymal cells is to keep the fluid in the brain moving around, what happens when the cilia on these cells are longer than they’re supposed to be?
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8 sinne gevind in 4 ms. Hulle kom uit baie bronne en word nie nagegaan nie.