hereditary breast ovarian cancer oor Portugees
hereditary breast ovarian cancer
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Síndrome de cancro hereditário da mama e ovário
en
autosomal dominant disease characterized by the higher than normal tendency to develop breast and ovarian cancers in genetically related families
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The familial tendency to develop these cancers is called hereditary breast–ovarian cancer syndrome.
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For example, through collaboration with physicians in Iran, Moslehi conducted studies on Iranian hereditary breast and ovarian cancer families, which led to the discovery of a novel BRCA1 mutation.
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Some of these syndromes include: certain inherited mutations in the genes BRCA1 and BRCA2 with a more than 75% risk of breast cancer and ovarian cancer, and hereditary nonpolyposis colorectal cancer (HNPCC or Lynch syndrome), which is present in about 3% of people with colorectal cancer, among others.
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He studies various aspects of cancer prevention and screening, proving that prophylactic surgeries and medications can prevent hereditary breast/ovarian cancers.
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Roxana has also made significant contributions to research on modifiers of BRCA-associated breast and ovarian cancer risk as well as to the understanding of mechanistic and population genetic aspects of the BRCA genes, now the most studied hereditary cancer predisposing genes in the human genome.
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