transdifferentiation oor Portugees
transdifferentiation
en
(biology) The change of one type of differentiated cell into another; metaplasia
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transdiferenciação
en
The conversion of a differentiated cell of one fate into a differentiated cell of another fate without first undergoing cell division or reversion to a more primitive or stem cell-like fate.
Endlessly recycles its own cells through a process called transdifferentiation, a kind of lineage reprogramming.
Recicla infinitamente as suas próprias células através de um processo chamado transdiferenciação, um tipo de reprogramação de linhagem.
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Endlessly recycles its own cells through a process called transdifferentiation, a kind of lineage reprogramming.
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This process is known as transdifferentiation (Collas and Hakelien 2003). 23.
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Transdifferentiation will directly grow an organ with your genetic makeup.
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Transdifferentiation.
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Additionally, it has been determined that the somatic expression of combined transcription factors can directly induce other defined somatic cell fates (transdifferentiation); researchers identified three neural-lineage-specific transcription factors that could directly convert mouse fibroblasts (skin cells) into fully functional neurons.
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Its cells undergo a process called transdifferentiation.
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The cell regeneration process, called transdifferentiation, is unique to the animal kingdom.
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To relate regeneration, transdifferentiation and metaplasia.
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It is emerges like a new treatment modality of cardiac diseases, so, an evaluation in cell distribution and quantification by different routes of infusion in heart are necessary, because the microenvironment and the interaction cell/cell age in the transdifferentiation and fusion process.
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These miRNAs are involved in mesodermal precursor differentiation, in transdifferentiation/ reprogramming of adult fibroblasts/myofibroblasts into mature cardiomyocytes, and preservation of normal function and survival of cardiomyocytes.
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We are also involved in projects looking at stimulation of mitochondrial metabolism during hepatic regeneration and transdifferentiation of adipose tissue.
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The process of switching one differentiated cell type into another cell type with a different form and function, such as transdifferentiation from hepatic stellate cells to myofibroblastic cells in liver fibrogenesis.
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This phenomenon is called browning, in small animals it can be obtained also by administration of beta3 agonists (43) and our as well as other’s studies suggest that it is due to direct conversion (transdifferentiation) of white adipocytes into brown adipocytes (43, 46, 47).
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This study enabled the plasticity of mesenchymal cells (MCs) in neuronal and glial nineage and opened prospects for the search with cell therapy and transdifferentiation
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We showed with different techniques, including lineage tracing and explants experiments, white-pink-white transdifferentiation, thus offering a new example of physiologic reversible transdifferentiation phenomenon in adipose organ (70-72)
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To identify preneoplastic lesions, regenerative and with transdifferentiation through histological and immunohistochemical observation.
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Additionally, it has been determined that the somatic expression of combined transcription factors can directly induce other defined somatic cell fates (transdifferentiation); researchers identified three neural-lineage-specific transcription factors that could directly convert mouse fibroblasts (skin cells) into fully functional neurons.[27] This result challenges the terminal nature of cellular differentiation and the integrity of lineage commitment; and implies that with the proper tools, all cells are totipotent and may form all kinds of tissue.
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The first studies showing the potential of neural transdifferentiation of mesenchymal stem cells (MSCs) from bone marrow (BM) were conducted in camundogos and humans in the early 2000s.
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To relate regeneration, transdifferentiation and metaplasia.
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In 2003, Li et al. discovered that the utricular epithelium of adult mammals contain support cells with progenitor properties (6), while in the mature Corti organ, transdifferentiation of non-sensitive cells was only observed in cilliary cells with gene induction.
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However, only in the case of GP7TB cells, the alterations suggested a differentiation/transdifferentiation process. The up-regulation of genes involved in pluripotency and genes expressing stem cell markers indicated that NaBu triggered a deep reprogramming of GP7TB cells.
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While confirming ADSC pluripotency, Chavez-Munoz et al.16 observed that these cells have the ability to transdifferentiate into epidermal keratinocytes and stratified epidermis.
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After the death of cilliary cells, the non-sensory support cells receive molecular or genetic signals, which initiate proliferation or transdifferentiation in immature ciliary cells.
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