nicotinic acetylcholine receptor oor Sweeds
nicotinic acetylcholine receptor
en
(biochemistry) acetylcholine receptors which are also ion channels
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Nikotinreceptor
en
chemical compound
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The active substance in CHAMPIX, varenicline, can bind to some of these receptors, the # nicotinic acetylcholine receptors
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Electrophysiology studies in vitro and neurochemical studies in vivo have shown that varenicline binds to the # neuronal nicotinic acetylcholine receptors and stimulates receptor-mediated activity, but at a significantly lower level than nicotine
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Varenicline binds with high affinity and selectivity at the # neuronal nicotinic acetylcholine receptors, where it acts as a partial agonist-a compound that has both agonist activity, with lower intrinsic efficacy than nicotine, and antagonist activities in the presence of nicotine
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These effects are caused primarily by activation of nicotinic acetylcholine receptors (nAChRs).
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Monepantel blocks part of a receptor, the nicotinic acetylcholine receptor, that is specific to the nematodes. This causes paralysis and death of the worms.
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One of the active substances in Trifexis, spinosad, interferes with receptors in the fleas’ nervous system (nicotinic acetylcholine receptors), resulting in subsequent paralysis and death of the fleas.
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Varenicline, the active ingredient of Champix is as a high-affinity nicotinic receptor partial agonist, meaning it binds to the nicotinic acetylcholine receptor subtype (nACH) that leads to the release of dopamine in the nucleus accumbens when activated.
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Varenicline, the active ingredient of Champix works as a nicotinic receptor partial agonist, meaning that it stimulates the same receptors in the brain that are susceptible to nicotine, most notably, acetylcholine receptors which are closely linked to heightened subjective experience of perception and reward.
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Further, such compounds may be advantageous over direct agonists in that the function of nicotinic receptors are only affected when the endogenous ligand, acetylcholine, is released by naturally occurring synaptic transmission.
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