methotrexate sodium
氨甲喋呤 · 氨甲蝶呤 · 甲氨蝶呤
methotrexate oor Sjinees
methotrexate
en
(medicine) An antimetabolite and antifolate drug used in treatment of cancer and autoimmune diseases.
Vertalings in die woordeboek Engels - Sjinees
氨甲喋呤
氨甲蝶呤
en
chemical compound
甲氨蝶呤
and very high-dose Methotrexate.
以及高剂量的甲氨蝶呤。
维生素拮抗物
抗维生素药
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Other commonly used medications include hydroxychloroquine, penicillamine, azathioprine, methotrexate, etanercept, anakinra, tocilizumab cyclophosphamide, adalimumab, rituximab, and infliximab.
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• The Haematology and Immunology Institute is unable to monitor the effects of the drug Methotrexate (MTX), used for the treatment of leukaemia and other lymphoproliferative syndromes, because the Institute has not been able to access diagnostic systems such as ARK Methotrexate Assay from the firm ARK Diagnostics Inc. of California, which as a United States company cannot trade with Cuba.
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Two clear examples of this phenomenon are Benzathine penicillin, the antibiotic of choice for certain bacterial infections, and methotrexate, used to treat arthritis, psoriasis, and certain cancers.
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This block of nucleotide biosynthesis is more toxic to rapidly growing cells than non-dividing cells, since a rapidly growing cell has to carry out DNA replication, therefore methotrexate is often used in cancer chemotherapy.
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Actually I had Cisplatin, Doxorubicin and very high-dose Methotrexate.
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Another example of the structural similarity of some inhibitors to the substrates of the enzymes they target is seen in the figure comparing the drug methotrexate to folic acid.
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Alcohol intake should be strictly avoided, as it may increase the liver toxicity of methotrexate. Methotrexate may harm an unborn baby, so it is very important that contraceptive precautions are taken when a young person becomes sexually active. 7.4 Main paediatric rheumatic diseases indications Juvenile idiopathic arthritis .
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Physicians use this term for drugs produced with biological engineering, which, unlike methotrexate or leflunomide, are primarily directed against specific molecules (tumour necrosis factor or TNF, interleukin 1, interleukin 6 or a T cell stimulatory molecule).
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Methotrexate therapy is usually long-term up to several years. Most physicians recommend treatment to continue for at least 6-12 months after disease control (remission) is achieved.
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13.1.2 Infliximab Description: Infliximab is a chimeric (part of the drug is derived from mouse protein) monoclonal antibody. Monoclonal antibodies link to TNF, thereby blocking or decreasing the inflammation process that is the basis of juvenile idiopathic arthritis. Dosage/modes of administration: Infliximab is administered intravenously in a hospital setting, after a more frequent induction regime it is usually every 8 weeks (6 mg/kg at each infusion) in association with methotrexate to decrease its side effects.
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The anti-TNF agents are used either alone or in combination with methotrexate.
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7.3 Side effects Most children on methotrexate have very few side effects.
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The most frequent adverse effects seen with methotrexate are nausea and abdominal distress on the day of intake.
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They are used alone or in association with methotrexate and are effective in most patients.
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Physicians use this term for drugs produced through biological engineering, which, unlike methotrexate or leflunomide , are primarily directed against specific molecules (tumour necrosis factor or TNF, interleukin 1 or 6, T cell receptor antagonist) in the inflammatory pathway.
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Regular blood tests are therefore needed during methotrexate therapy.
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Methotrexate Has Negative Side Effects on Rheumatoid Arthritis
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Methotrexate 7.1 Description Methotrexate is a drug that has been used in children suffering from a number of different paediatric rheumatic diseases for many years.
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If they are being treated with methotrexate, proper birth control should be used, since the drug may have side effects on a foetus.
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It was first proven for systemic and later for polyarticular JIA and it can be used in patients who donot respond to methotrexate or other biologic agents.
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Treatment for Reiter's Syndrome is similar to psoriasis, except methotrexate is a relative contraindication (130 , 28 ).
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Like for methotrexate, regular laboratory tests are therefore needed.
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The risk of infections is usually not increased in children treated with methotrexate.
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The most frequent laboratory abnormality is an increase in liver enzymes, which normalizes with drug withdrawal or with methotrexate dose reduction.
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However, severe disease and vital organ involvement requires early addition of other medication, usually cyclophosphamide , in order to achieve disease control (so-called induction therapy). In cases with severe and unresponsive disease, other drugs including biologic agents are sometimes used but their efficacy in PAN has not been formally studied. Once disease activity settles, it is kept under control with maintenance therapy, usually with azathioprine , methotrexate or mycophenolate mophetil .
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40 sinne gevind in 10 ms. Hulle kom uit baie bronne en word nie nagegaan nie.