본 발명은 카바페넴계 첨단 항생물질인 메로페넴·삼수화물[(1R,5S,6S)-2-[((2'S,4'S)-2'-디메틸아미노카르보질)피롤리딘-4'-일티오]-6-[(R)-1-히드록시에틸]-1-메틸카르바벤-2-엠-3-카르복실산, 삼수화물]의 개선된 합성방법에 관한 것이다.
The present invention relates to an improved method for synthesizing meropenem trihydrate [(1R,5S,6S)-2-[((2'S,4'S)-2'-dimethylaminocarbozyl)pyrrolidin-4'-ylthio]-6-[(R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylic acid, trihydrate], which is a novel carbapenem antibiotic.patents-wipo patents-wipo