Metadata
Author: patents-wipo
Data
English[en]
More specifically, it has been confirmed that an Ardisia tinctoria extract or a fraction thereof suppresses the production of nitric oxide which is sharply increased by inflammation induction, and it has been confirmed that the Ardisia tinctoria extract is effective in markedly reducing the amount of PGE2, IL-6 (interleukin-6) and IL-1 beta cytokine in a dose dependent fashion, and that it inhibits the expression of iNOS and the COX2 gene and protein and inhibits nuclear translocation of p65 protein and phosphorylation of signal transducers.
French[fr]
Plus spécifiquement, il a été confirmé qu'un extrait ou une fraction d'Ardisia tinctoria supprimait la production d'oxyde nitrique qui est considérablement accrue par l'induction de l'inflammation, que ledit extrait d'Ardisia tinctoria était efficace pour réduire de façon notable la quantité de PGE2, d'IL-6 (interleukine-6) et de cytokine IL-1 bêta proportionnellement à la dose administrée, et qu'il permettait d'inhiber l'expression d'iNOS et de la protéine et du gène COX2, et également d'inhiber la translocation nucléaire de la protéine p65 et la phosphorylation de transducteurs du signal.
Korean[ko]
추출물 및 이의 분획물을 함유하는 염증성 질환 예방 및 치료용 조성물에 관한 것으로, 보다 상세하게는 알디시아 팅크토리아 추출물 또는 이의 분획물이 염증 유발에 의해 급격히 증가하는 나이트릭옥사이드 생성을 저해함을 확인하였으며, 알디시아 팅크토리아 추출물은 농도의존적으로 PGE2 및 IL-6(interleukin-6)와 IL-1beta 사이토카인의 양을 현저하게 낮추는 효과가 있었으며, iNOS 및 COX-2 유전자 및 단백질의 발현을 억제함과 p65단백질의 핵전이와 신호전달물질의 인산화를 억제함을 확인하였다.