Metadata
Author: WikiMatrix
Data
English[en]
DNA damage can induce apoptosis when the ATM kinase and Chk2 phosphorylate p53 on its Ser-15 and Ser-20 residues which activates p53 and stabilizes it by allowing it to dissociate from the E3 ubiquitin protein ligase MDM2.
Galician[gl]
Os danos no ADN poden inducir a apoptose cando a quinase ATM e Chk2 fosforilan p53 nos seus residuos Ser-15 e Ser-20, o cal activa p53 e estabilízao ao permitir que se disocie da E3 ubiquitina proteína ligase MDM2.