On reaction of the disodium salt of 6-chloro-4-phenyl-3,4-dihydro-1H-2,1,3-benzothiadiazine-2,2-dioxide (1) with 1,4-diiodobutane inDMF the expected 1,3-butano derivative was not obtained. On the one hand1 was dehydrogenated to give 6-chloro-4-phenyl-1H-2,1,3-benzothiadiazine-2,2-dioxide (4), on the other hand according to the method of preparation of the disodium salt either methylation reactions occured or 6-chloro-1-(4-iodobutyl)-4-phenyl-3,4-dihydro-1H-2,1,3-benzothiadiazine-2,2-dioxide (7) and 6,6′-dichloro-4,4′-diphenyl-3,3′,4,4′-tetrahydro-3,3′-tetramethylenebis(1H-2,1,3-benzothiadiazine)-2,2,2′,2′-tetroxide (8) were formed.
Diese Untersuchungen sollten daher von qualifizierten Ermittlern unter der Kontrolle einer unabhängigen Stelle oder Einrichtung durchgeführt werden, damit Interessenkonflikte vermieden werdenspringer springer