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Rats chronically exposed to PFOA resulted in increased incidences of liver adenomas, Leydig cell hyperplasia/adenomas and pancreatic acinar cell tumours (PACT) in male Sprague-Dawley rats (Biegel et al., 2001).UN-2 UN-2
Increased incidences of other tumours including brain gliomas in male and female rats, liver carcinomas in male mice, benign vascular tumours in female mice, and liver adenomas and carcinomas in female rats were seen only at high lifetime exposuresEMEA0.3 EMEA0.3
According to the NTP report (1986) there is some evidence at high dose levels for an increase in liver adenoma in rats and liver adenoma and carcinoma in mice, but this may be related to a secondary mode of action (EFSA 2011).UN-2 UN-2
Animal studies have shown that APFO induces liver adenomas, Leydig cell adenomas, and pancreatic acinar cell tumours (PACT) in male Sprague-Dawley rats (Sibinski et al., 1987 cited in ECHA, 2011), and increase incidences of mammary fibroadenoma in the female rats (Biegel, 2001 cited in ECHA, 2011).UN-2 UN-2
In mice dose-related gastric ECL cell hyperplasia developed as well as liver tumours and adenoma of rete testisEMEA0.3 EMEA0.3
In mouse carcinogenicity studies dose-related gastric ECL cell hyperplasia developed as well as liver tumours and adenoma of rete testisEMEA0.3 EMEA0.3
Certain benign liver tumors, such as hepatocellular adenoma, may sometimes be associated with coexisting malignant HCC.WikiMatrix WikiMatrix
Rodent studies showed dose-related increases in adenomas and carcinomas in the liver, thyroid, and kidney.UN-2 UN-2
Rodent studies showed dose related increases in adenomas and carcinomas in the liver, thyroid, and kidney.UN-2 UN-2
Rodent studies showed dose related increases in adenomas and carcinomas in the liver, thyroid, and kidneyMultiUn MultiUn
Rodent studies showed dose-related increases in adenomas and carcinomas in the liver, thyroid, and kidneyMultiUn MultiUn
In rats, administration of maraviroc at a systemic exposure #-times the expected human exposure produced thyroid adenomas associated with adaptive liver changesEMEA0.3 EMEA0.3
The EU concluded that rodent studies showed dose related increases in adenomas and carcinomas in the liver, thyroid, and kidney.UN-2 UN-2
The EU concluded that rodent studies showed dose related increases in adenomas and carcinomas in the liver, thyroid, and kidneyMultiUn MultiUn
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