sarcoma growth factor oor Spaans
sarcoma growth factor
Vertalings in die woordeboek Engels - Spaans
factor de crecimiento del tumor
factor de crecimiento transformante
Geskatte vertalings
Vertoon algoritmies gegenereerde vertalings
voorbeelde
Advanced filtering
Voorbeelde moet herlaai word.
Synovial sarcoma has no known risk factors, but genetics may play a role in its growth.
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Monoclonal antibodies against the insulin-like growth factor 1 receptor (IGF1R) are reported to produce objective responses in metastatic recurrent Ewing sarcoma in roughly 10% of cases.
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In a phase II trial of cediranib, an inhibitor of all three known vascular epidermal growth factor receptors, 15 of 43 adult patients (35%) with metastatic alveolar soft part sarcoma had partial responses.
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Monoclonal antibody therapy. Monoclonal antibodies against the insulin-like growth factor 1 receptor (IGF1R) are reported to produce objective responses in metastatic recurrent Ewing sarcoma in roughly 10% of cases.[27-30][Level of evidence: 3iiDiv] In these studies, it was suggested that time-to-progression was prolonged compared with historical controls.
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Monoclonal antibody therapy. Monoclonal antibodies against the insulin-like growth factor 1 receptor (IGF1R) are reported to produce objective responses in metastatic recurrent Ewing sarcoma in roughly 10% of cases.[24-27][Level of evidence: 3iiDiv] In these studies, it was suggested that time-to-progression was prolonged compared with historical controls.
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Gene expression profiling and IHC data has indeed identified abnormal up-regulation of multiple well-known oncogenes in clear cell sarcoma, such as those encoding the growth/survival-related receptor tyrosine kinases c-Kit, c-Met, and ERBB3, the anti-apoptotic regulator protein BCL-2, the neural crest-specific SOX10 transcription factor, and the melanocytic master transcription factor MITF.16,18,42,49,50 These genes have been implicated in a variety of cancers as they regulate a common set of cell signalling pathways contributing to uncontrolled growth, invasion, and angiogenesis.
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6 sinne gevind in 14 ms. Hulle kom uit baie bronne en word nie nagegaan nie.