oncogene oor Indonesies
oncogene
en
(oncology, genetics) Any gene that contributes to the conversion of a normal cell into a cancerous cell when mutated or expressed at high levels.
Vertalings in die woordeboek Engels - Indonesies
Onkogen
en
gene that has the potential to cause cancer
onkogen
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Vertoon algoritmies gegenereerde vertalings
voorbeelde
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Voorbeelde moet herlaai word.
BMI1 is a polycomb ring finger oncogene.
Aku tidak tahu ituWikiMatrix WikiMatrix
In other words, mutant tumor suppressors' alleles are usually recessive whereas mutant oncogene alleles are typically dominant.
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Mutations in the K-ras proto-oncogene cause roughly 10–30% of lung adenocarcinomas.
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A proto-oncogene is a normal gene that could become an oncogene due to mutations or increased expression.
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Unlike oncogenes, tumor suppressor genes generally follow the "two-hit hypothesis," which implies that both alleles that code for a particular protein must be affected before an effect is manifested.
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Somatic amplification of the MYCN oncogene is responsible for some cases of non-hereditary, early-onset, aggressive, unilateral retinoblastoma.
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Proto-oncogenes code for proteins that help to regulate the cell growth and differentiation.
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The antigens expressed by tumors have several sources; some are derived from oncogenic viruses like human papillomavirus, which causes cervical cancer, while others are the organism's own proteins that occur at low levels in normal cells but reach high levels in tumor cells.
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A third possible source of tumor antigens are proteins normally important for regulating cell growth and survival, that commonly mutate into cancer inducing molecules called oncogenes.
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Abnormal amounts of gene product can be correlated with disease-causing alleles, such as the overactivity of oncogenes which can cause cancer.
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Oncogene is a peer-reviewed scientific journal published by the Nature Publishing Group addressing cancer cell genetics and the structure and function of oncogenes.
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These proteins appear to be distant relatives of the Tet1 oncogene that is involved in the pathogenesis of acute myeloid leukemia.
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Working with Harold E. Varmus in the 1980s, he discovered the first human oncogene, c-Src.
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Oncogene mutations, in contrast, generally involve a single allele because they are gain-of-function mutations.
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The loss of these genes may be even more important than proto-oncogene/oncogene activation for the formation of many kinds of human cancer cells.
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The results of several studies suggest that calcineurin inhibitors have oncogenic properties mainly linked to the production of cytokines that promote tumor growth, metastasis and angiogenesis.
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Src inhibitor is a class of inhibitors that targets src kinase family, which is transcribed by proto-oncogenes src genes (abbreviating for sarcome genes) that potentially induced cell of malignant transformation.
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Furthermore, increased mutation rate from decreased DNA repair leads to increased inactivation of other tumor suppressors and activation of oncogenes.
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The leader of the research team which discovered this, geneticist Pier Paolo Pandolfi from the Memorial Sloan-Kettering Cancer Center (MSKCC) in New York City, said the gene is unique in that it is needed for other oncogenes to cause cancer.
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On 8 February 2020, the laboratory OncoGen in Romania published a paper on the design of a vaccine with similar technology to the one used for cancer neoantigen vaccination therapy.
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In acutely transforming viruses, the viral particles carry a gene that encodes for an overactive oncogene called viral-oncogene (v-onc), and the infected cell is transformed as soon as v-onc is expressed.
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Proto-oncogenes are often involved in signal transduction and execution of mitogenic signals, usually through their protein products.
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22 sinne gevind in 8 ms. Hulle kom uit baie bronne en word nie nagegaan nie.