Na+/K+-ATPase oor Bulgaars

Na+/K+-ATPase

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They also shared the prize with Danish chemist Jens C. Skou for research unrelated to theirs (Discovery of the Na+/K+-ATPase).
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Spermidine synchronizes an array of biological processes (such as Ca2+, Na+, K+ -ATPase) thus maintaining membrane potential and controlling intracellular pH and volume.
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"for the first discovery of an ion-transporting enzyme, Na+, K+ -ATPase"
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This process results in a vicious cycle down the chain: Low NA-K-ATPase activity – high natriuria levels in the nephron's proximal end – suppression of renin secretion by the JGA and developing hyporeninemia – maintaining hypoangiotensin II-emia – low Na-H+ exchanger count in renal tubular epithelial cells – low sodium-potassium ATPase activity.
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