therapeutic exposure oor Spaans

therapeutic exposure

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exposición terapéutica

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The radiation dose resulting from therapeutic exposure may result in higher incidence of cancer and mutations
La dosis de radiación resultante de la exposición terapéutica puede causar un aumento de la incidencia de cáncer y de mutaciones
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In male mice altered hepatocellular foci were seen at doses that were at least # times human therapeutic exposure
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Second, therapeutic exposure is predictable and under the patient's control.
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The radiation dose resulting from therapeutic exposure may result in higher incidence of cancer and mutations
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The radiation dose resulting from therapeutic exposure may result in higher incidence of cancer and mutations
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The systemic exposure to lopinavir/ritonavir at the maternal and developmental toxic dosages was lower than the intended therapeutic exposure in humans
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Following inhalation the systemic exposure based on AUC values in rats exceeded the corresponding therapeutic exposure in human patients by approximately # times
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However, it should be noted that systemic exposure in rodents was similar or even lower than therapeutic exposure in humans at the # mg/# mg dose
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In animal studies at systemic plasma exposures (AUC) to amprenavir lower than therapeutic exposure in patients treated with Telzir, some developmental toxicity was observed (see section
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In animal studies at systemic plasma exposures (AUC) to amprenavir lower than therapeutic exposure in patients treated with Telzir, some developmental toxicity was observed (see section
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No overt teratogenic or primary foetotoxic effects were observed in animal studies in which the exposure levels of entacapone were markedly higher than the therapeutic exposure levels
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In the single-dose dog infusion studies, # mg/kg (# fold the recommended human therapeutic exposure based on AUC) administered over # minutes was well tolerated with no renal effects
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The potential for reproductive toxicities of fosaprepitant and aprepitant have not been fully characterized, since exposure levels above the therapeutic exposure in humans were not attained in animal studies
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Radioactive Sm-EDTMP has not been tested for mutagenicity/carcinogenicity but due to the radiation dose resulting from therapeutic exposure it should be regarded as presenting a genotoxic/carcinogenic risk
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In rats the incidence of pre-implantation loss was increased at a dose of # mg/kg/day, (# times the human therapeutic exposure following a dose of # mg), which caused maternal toxicity
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The potential for reproductive toxicity of aprepitant has not been fully characterized, since exposure levels above the therapeutic exposure in humans at the # mg/# mg dose were not attained in animal studies
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However, in a # month study in dogs, no organ weight changes nor gross or histomorphologic findings were present in male reproductive organs at systemic exposures #-fold above the therapeutic exposure in humans at # mg
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Although no adverse effects were noted in reproduction studies when female animals were exposed #-to #-fold above the therapeutic exposure in humans at # mg, the potential effects on reproduction of alterations in neurokinin regulation are unknown
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Therapeutic radiation exposure 9.
Mientras la base de datos encargada del archivo de los documentos por incluir en el registro no sea operativa, el servicio encargado del registro utilizará los sistemas y las bases de datos ya existentes en el Parlamento Europeo y se limitará a establecer los enlaces con estas últimas, con el fin de extraer los datos necesarios y facilitar el acceso a los textos íntegros de los documentosLiterature Literature
No compound-related tumours were observed in a #-year rat study with prasugrel exposures ranging to greater than # times the recommended therapeutic exposures in humans (based on plasma exposures to the active and major circulating human metabolites
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444 sinne gevind in 15 ms. Hulle kom uit baie bronne en word nie nagegaan nie.