Human cytochrome oor Kroaties

Human cytochrome

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Humani citokromi

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humane cytochrome
humani citokrom

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Ibogaine is metabolized in the human body by cytochrome P450 2D6 into noribogaine (more correctly, O-desmethylibogaine or 12-hydroxyibogamine).
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These flavonoids had shown, in earlier research on human liver microsomes, metabolism mediated by cytochrome P450.
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CYP2B6 is one of the numerous members of the cytochrome P450 family and constitutes 2% to 10% of the total hepatic cytochrome content in humans.
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In vitro metabolism data and the human mass balance study results indicated that the cytochrome P450 system is not involved in the metabolism of decitabine.
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In-vitro studies on dexrazoxane in human microsomes have shown high stability of dexrazoxane indicating that major metabolism via cytochrome P450 is unlikely.
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Human liver microsomes are ideal system for monitoring the metabolic activity because cytochrom P450 enzymes are linked to membranes of endoplasmatic reticulum and are expressed in liver.
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In humans, porphyrins are the main precursors of heme, an essential constituent of hemoglobin, myoglobin, catalase, peroxidase, respiratory and P450 liver cytochromes.
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