fingolimod oor Italiaans
fingolimod
en
An immunosuppressive drug.
Vertalings in die woordeboek Engels - Italiaans
Fingolimod
en
chemical compound
it
farmaco
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In September 2010, fingolimod became the first oral disease-modifying drug approved by the Food and Drug Administration to reduce relapses and delay disability progression in patients with relapsing forms of multiple sclerosis.
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The molecular biology of phospho-fingolimod is thought to lie in its activity at one of the five sphingosine-1-phosphate receptors, S1PR1.
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Gilenya contains the active substance fingolimod in capsules for oral use and has been approved as a disease modifying therapy in highly active relapsing remitting multiple sclerosis.
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Nintedanib and MP-0766, a drug acting as an angiokinase inhibitor and a new fingolimod analogue devoid of immunosuppressive action, activating respectively SHP-1 and PP2A have enabled for the discovery of a signalling axis that when activated provokes massive cell death, and might provide a new paradigm for the treatment of CLL, which now endorses kinase inhibitors.
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Its activity is due to the fact that, once internalized by the cell, it gets phosphorylated and reaches a structural similarity with sphingosine-1-phosphate (S1P), mimicking it on T cells: by overstimulating S1P receptors, indeed, Fingolimod can lead to their degradation, avoiding the possibility for T cells to egress secondary lymphoid organs and to keep on damaging neural axons.
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Combining all the pieces of information obtained from these aims will lead both to an enhanced knowledge about the structural interactions between PP2A and SET (which to date is lacking) and to the possibility of rationalize eventual structure-activity relationships between the proteins of interest and anti-cancer compounds; this will help in elucidating the structural characteristics which are needed for the molecules to be active, and as a consequence in designing more, improved, rationalized Fingolimod analogs.
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However the safety profile of fingolimod raises doubts mainly because this drug is approved as a first choice treatment, whilst EMA denied this indication for Europe.
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In more recent years, it has been shown that Fingolimod can restore PP2A activity in tumors as a side effect; the mechanism underlying this event is still not clear, but it is probably due to the interaction Fingolimod has with the PP2A/SET complex.
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It is important to underline that even assuming the best use of all available information, which is unfortunately rare, it does not allow to reach high accuracy in prediction, however it implies already a substantial increase in quality of care for the patient with MS. Moving on to the evaluation of the available therapeutic resources for relapsing forms of the disease, it is important to distinguish between first-line drugs, including interferons and glatiramer, and second line drugs including natalizumab, mitoxantrone and fingolimod.
L incidenza di guarigione completa (imiquimod meno placebo) per gli studi clinicicombinati è stata del # % (IC # %, # %ParaCrawl Corpus ParaCrawl Corpus
Combining all the pieces of information obtained from these aims will lead both to an enhanced knowledge about the structural interactions between PP2A and SET (which to date is lacking) and to the possibility of rationalize eventual structure-activity relationships between the proteins of interest and anti-cancer compounds; this will help in elucidating the structural characteristics which are needed for the molecules to be active, and as a consequence in designing more, improved, rationalized Fingolimod analogs.
enti pubblici a livello regionale o locale; oParaCrawl Corpus ParaCrawl Corpus
Nintedanib and MP-0766, a drug acting as an angiokinase inhibitor and a new fingolimod analogue devoid of immunosuppressive action, activating respectively SHP-1 and PP2A have enabled for the discovery of a signalling axis that when activated provokes massive cell death, and might provide a new paradigm for the treatment of CLL, which now endorses kinase inhibitors. abstract_it:
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Fingolimod is a product designed for treating multiple sclerosis which exerts its immunosuppressive activity by inhibiting the lymphocytes efflux into the lymph nodes.
Il risultato è stata una grandissima disparità tra ricchi e poveri e il diffuso fenomeno della povertà infantile, a differenza dei paesi che investono nelle spese per il settore sociale e riducono il divario tra abbienti e meno abbienti.ParaCrawl Corpus ParaCrawl Corpus
Novartis said it does not know of any confirmed PML cases in patients treated with Gilenya, also known as fingolimod, who were not previously been treated with Tysabri. The company said details on the case were being submitted to the health authorities.
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This thesis work presents the synthesis and characterization of a library of Fingolimod analogs which are meant to isolate the pro-apoptotic effect from the immunosuppressive one.
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Have been selected to 1,272 patients with multiple sclerosis, intermittent, randomly assigned to a group who received fingolimod at a dose of 0.5 mg daily, and a second treated at a dose of 1.25 mg, both controlled double-blind to a placebo over a period of 24 months.
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Fingolimod (IUPAC name 2-amino-2-[2-(4-octylphenyl)ethyl]propan-1,3-diol) has been approved in 2010 for the treatment of relapsing-remitting forms of multiple sclerosis.
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Combining all the pieces of information obtained from these aims will lead both to an enhanced knowledge about the structural interactions between PP2A and SET (which to date is lacking) and to the possibility of rationalize eventual structure-activity relationships between the proteins of interest and anti-cancer compounds; this will help in elucidating the structural characteristics which are needed for the molecules to be active, and as a consequence in designing more, improved, rationalized Fingolimod Calin, G. A.
IntroduzioneParaCrawl Corpus ParaCrawl Corpus
Keeping in mind that Fingolimod acts on PP2A only if unphosphorylated, this means designing and synthesizing molecules with modulated structural characteristics, but with a peculiar focus on their phosphorylatability.
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Professor Comi is part of an international research team presenting the latest results of a study involving the orally administered drug fingolimod that is still in the clinical trial state and yet to be approved.
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Curiously, this activity needs Fingolimod not to be phosphorylated.
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An earlier study showed that oral fingolimod reduced the annualizied relapse rate in MS patients by more than 50 percent versus placebo.
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The impact of oral therapy with Fingolimod on the cognitive functions of Relapsing Remitting Multiple Sclerosis patients
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Fingolimod, teriflunomide, and dimethyl fumarate, which are relatively new drugs, may be used to treat multiple sclerosis that occurs in relapsing patterns.
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Consistent with efficacy results observed for patients switching from beta interferon or glatiramer acetate to TYSABRI, for patients switching from fingolimod (n=147) to TYSABRI, a significant decrease in annualised relapse rate (ARR) was observed, which remained stable over 2 years, and mean EDSS scores remained similar from baseline to Year 2.
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Patients with multiple sclerosis and intermittent broad spectrum of clinical signs detected on magnetic resonance imaging to the visit and may receive a benefit from daily treatment with 0.5 mg of fingolimod.
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