Aliskiren oor Spaans
Aliskiren
Vertalings in die woordeboek Engels - Spaans
Aliskiren
Aliskiren was devoid of any mutagenic potential in the in vitro and in vivo mutagenicity studies
Aliskiren no mostró potencial mutagénico en los estudios de mutagenicidad in vitro e in vivo
Geskatte vertalings
Vertoon algoritmies gegenereerde vertalings
aliskiren
en
(medicine) A renin inhibitor that is used in the treatment of hypertension
Vertalings in die woordeboek Engels - Spaans
Aliskiren
en
first in a class of drugs called direct renin inhibitors
es
compuesto químico
The most likely manifestations of overdosage would be hypotension, related to the antihypertensive effect of aliskiren
La manifestación más probable de una sobredosis sería hipotensión, relacionada con el efecto antihipertensivo de aliskiren
Geskatte vertalings
Vertoon algoritmies gegenereerde vertalings
voorbeelde
Advanced filtering
Voorbeelde moet herlaai word.
Aliskiren plasma protein binding is moderate (# %) and independent of the concentration
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By inhibiting the enzyme renin, aliskiren inhibits the RAS at the point of activation, blocking the conversion of angiotensinogen to angiotensin I and decreasing levels of angiotensin I and angiotensin
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Moderate P-gp inhibitors Co-administration of aliskiren # mg with ketoconazole # mg resulted in a # % increase in aliskiren AUC but P-gp inhibitors such as ketoconazole are expected to increase tissue concentrations more than plasma concentrations
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Relative AUC and Cmax of aliskiren in subjects with renal impairment ranged between # to # times the levels in healthy subjects following single dose administration and at steady state
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The studies compared the combination of aliskiren and hydrochlorothiazide with placebo (a dummy treatment), with aliskiren or hydrochlorothiazide taken alone, or with other medicines for hypertension (valsartan, irbesartan, lisinopril or amlodipine
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Although aliskiren has known irritation potential, safety margins obtained in humans at the dose of # mg during a study in healthy volunteers were considered to be appropriate at #-fold based on faecal concentrations or #-fold based on mucosa concentrations in comparison with # mg/kg/day in the rat carcinogenicity study
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The most likely manifestations of overdosage would be hypotension, related to the antihypertensive effect of aliskiren
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Each Rasilez HCT # mg/# mg film-coated tablet contains # mg aliskiren (as
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Each film-coated tablet contains # mg aliskiren (as hemifumarate
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Rasilez HCT # mg/# mg film-coated tablets Aliskiren/hydrochlorothiazide
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P-gp potent inhibitors A single dose drug interaction study in healthy subjects has shown that ciclosporin (# and # mg) increases Cmax of aliskiren # mg approximately #-fold and AUC approximately #-fold
Kinzalkomb # mg/# mg comprimidos telmisartán/hidroclorotiazidaEMEA0.3 EMEA0.3
In a study in # randomised patients with severe hypertension (mean sitting diastolic blood pressure # and < # mmHg), aliskiren treatment regimen with optional addition of hydrochlorothiazide # mg was shown to be safe and efficacious in reducing blood pressure
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Aliskiren was not teratogenic in rats or rabbits (see section
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The concomitant use of aliskiren with ciclosporin, a highly potent P-gp inhibitor, and other potent P-gp inhibitors (quinidine, verapamil), is contraindicated (see section
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Aliskiren is mainly eliminated as unchanged compound in the faeces (# %
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Co-administration of aliskiren with either valsartan (# %), metformin (# %), amlodipine (# %) or cimetidine (# %) resulted in between # % and # % change in Cmax or AUC of Enviage
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Posology in patients not adequately controlled with aliskiren or hydrochlorothiazide monotherapy Individual dose titration with each of the two components may be recommended before changing to the fixed combination
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more than plasma concentrations.Therefore caution should be exercised when aliskiren is administered with moderate P-gp inhibitors such as ketoconazole (see section
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Grapefruit juice Due to the lack of data a potential interaction between grapefruit juice and aliskiren cannot be excluded
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The proportion of patients who had UACR reduced at least # % from baseline to endpoint was # % and # % for aliskiren and placebo, respectively
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Patients receiving other medicinal products inhibiting the renin-angiotensin system (RAS), and/or those with reduced kidney function and/or diabetes mellitus are at an increased risk of hyperkalaemia during aliskiren therapy
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Due to the lack of data a potential interaction between grapefruit juice and aliskiren cannot be excluded
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In patients who did not adequately respond to # mg of the calcium channel blocker amlodipine, the addition of Enviage # mg had a blood-pressure-lowering effect similar to that obtained by increasing amlodipine dose to # mg, but had a lower incidence of oedema (aliskiren # mg/amlodipine # mg # % vs. amlodipine # mg # %
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Similar reductions were found when aliskiren was combined with other antihypertensive agents
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207 sinne gevind in 6 ms. Hulle kom uit baie bronne en word nie nagegaan nie.