non-coding regulatory region oor Spaans

non-coding regulatory region

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región reguladora no codificadora

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The decoding of the human and mouse genomes has unveiled about 20 000 protein-coding genes among a colossal number of non-coding regulatory regions.
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The project focused on cis-regulatory elements, or non-coding DNA regions, regulating transcription of the nearby genes.
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Cis-regulatory elements (CREs) are regions of non-coding DNA which regulate the transcription of neighboring genes.
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Instead, these non-coding regions are retained on the mature mRNA and act as regulatory sequences.
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This has significant ramifications for cancer research as it explains the aberrant expression of non-coding RNAs in cancer cells and illustrates the importance of regulatory regions.
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The HPV genome consists of 8 genes coding for proteins and a non-protein-coding region with regulatory genes.
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Therefore, it is not surprising that many of the large number of genome-wide association studies that have been reported in the last few years indicate that the lesions associated with human genetic diseases are usually not in the coding DNA of candidate genes, but rather in the non-coding regulatory regions associated with them (Maurano, 2012).
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The extensive polymorphisms revealed in non-coding gene-regulatory regions in the immune system, as well as genetic variations in drug-metabolizing enzymes, suggest that this type of variation is of functional and evolutionary importance and may provide clues for developing new therapeutic strategies.
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News A twist in celiac disease: the regulatory role of non coding regions.
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A twist in celiac disease: the regulatory role of non coding regions.
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These results provide evidence for the exclusion of this candidate as the PFHB1-causative gene, although mutations in regulatory and non-coding regions cannot be excluded.
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Non-coding regions may have specific chromosomal functions or have regulatory purposes.
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