Finally, as it has been suggested a role for Protein phosphatase 2 (PP2A)-mediated dephosphorization in cardiac morphogenesis and development in mouse and rat, and this protein interacts with AMBRA1 to control cell proliferation, co-injection of MOs with hAMBRA1 mRNA and with a messenger mutated in the PP2A binding sites (hAMBRA1PXP mRNA) was used to analyze their rescue effectiveness on heart.
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