A Lowest-Observed-Adverse-Effect-Level (LOAEL) of 1.17 mg/kg bw/day was recorded in a 3 month feeding study in rats and signs of toxicity included focal necrosis in liver, enlargement of the adrenal gland, tremor, hyperactivity and exaggerated startle response (Cannon and Kimbrough, 1979, as quoted in US ATSDR, 1995).
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