The 21-day Fish Endocrine Screening Assay underwent an extensive validation programme consisting of inter-laboratory studies with selected chemicals to demonstrate the relevance and reliability of the assay for the detection of oestrogenic and aromatase inhibiting chemicals (1, 2, 3, 4, 5) in the three fish species investigated (the fathead minnow, the Japanese medaka and the zebrafish); the detection of androgenic activity is possible in the fathead minnow and the medaka, but not in the zebrafish.
Tutkimuksessa V arvioitiin # aikuispotilasta, joilla oli keskivaikea tai vaikea aktiivinen varhaisvaiheen nivelreuma (taudin kesto keskimäärin alle # kuukautta) ja jotka eivät olleet saaneetEurLex-2 EurLex-2