In detail, the present invention provides animal models of disease using extracellular vesicles derived from gram-positive bacteria, provides a method for screening an active candidate substance which is capable of preventing or treating diseases through the animal models of disease, provides vaccines for preventing or treating diseases caused by extracellular vesicles derived from gram-positive bacteria, and provides a method for diagnosing the causative factors of diseases caused by gram-positive bacteria using extracellular vesicles.
본 발명은 둘 이상의 터널이 근접하게 시공될 때, 터널과 터널 사이의 지반이 기등체를 대신할 수 있도록 필라부를 보강하는 방법 및 굴착 시공 방법에 관한것이다.patents-wipo patents-wipo